Pharma Natural Valeriana 1000mg 2 Bottles x 30 Capsules each
A study examined longer-term effects [of Valerian] in 121 participants with documented nonorganic insomnia, a sleep disorder (difficulty in going to sleep or getting enough sleep) that occurs as a symptom of a physical or mental disease. Participants received either 600 mg of a standardized commercial preparation of dried valerian root or placebo for 28 days. After 28 days, the group receiving the valerian extract showed a decrease in insomnia symptoms compared with the placebo group. The differences in improvement between valerian and placebo increased between the assessments done on days 14 and 28. A possible mechanism by which a valerian extract may cause sedation is by increasing the amount of gamma aminobutyric acid (GABA, an inhibitory neurotransmitter). Valerian extracts contain GABA in quantities sufficient to cause a sedative effect. Regarding the use of valerian root in treating anxiety, in one 2002 study of 36 patients with generalized anxiety disorder, found that 50 mg of valerian root extract given three times a day for four weeks significantly reduced one measure of anxiety compared to placebo. Other anxiety studies used slightly higher dosages.